Tympanosclerosis: Tympanosclerosis refers to a variety of tissue changes that occur as the result of repeated middle ear infections. It is often seen as chalky white calcium plaques and scar tissue on the pars tensa of the eardrum, which has little if any effect on hearing sensitivity. Tympanosclerosis also affects the other structures of the middle ear, and can affect hearing if the calcification or other changes impair the mobility of the ossicular chain.